Endotyping, phenotyping, proteomics/omics biomarkers, and precision diagnostics.
33 tracked publications · last updated 2026-06-08
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Publications
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Heparin-like compounds improve the biophysical properties of eosinophilic mucus
Arima M et al. — Allergol Int (2026-06) · Original
Laboratory study showing heparin-like compounds reduce viscosity and increase hydrophilicity of eosinophil-extracellular-trap-rich mucus in eosinophilic chronic rhinosinusitis.
PubMed · DOI · PMID 42248766 -
Eosinophils in the immunologic spectrum of Eosinophilic Granulomatosis with Polyangiitis: From Fundamental Pathobiology to Emerging Therapeutic Strategies and Future Perspectives
Hasegawa R et al. — Intern Med (2026-06) · Review
Review of eosinophil pathobiology and IL-5-targeted therapy in EGPA, a vasculitis featuring CRSwNP.
PubMed · DOI · PMID 42236192 -
Chronic rhinosinusitis with nasal polyps (CRSwNP) through an epigenetic lens: Plasmacytoma variant translocation 1 (PVT1) as a potential biomarker and therapeutic target
Gangwar RS — Ann Allergy Asthma Immunol (2026-06) · Editorial
Editorial proposing the long non-coding RNA PVT1 as an epigenetic biomarker and therapeutic target in CRSwNP.
PubMed · DOI · PMID 42236047 -
Nasal nitric oxide is inversely associated with radiologic severity and eosinophilic inflammation in chronic rhinosinusitis
Kiyohara K et al. — Auris Nasus Larynx (2026-06) · Original
Cross-sectional study showing nasal nitric oxide is reduced in CRS and inversely correlates with CT severity and eosinophilia.
PubMed · DOI · PMID 42235128 -
Improvement of Mixed Inflammatory Environment in Nasal Secretions of Diffuse Type 2 Chronic Rhinosinusitis With Nasal Polyps Under Dupilumab
Ryser FS et al. — Clin Transl Allergy (2026-06) · Original
Nasal-secretion proteomics showing dupilumab reduces type 1/2/3 inflammatory markers and identifying GDNF as a treatment-response biomarker in type 2 CRSwNP.
PubMed · DOI · PMID 42233370 -
Potential Clinical Impact of Sinonasal Biofilms in CRS: A Structured Evidence Synthesis
Holley HA et al. — Int Forum Allergy Rhinol (2026-06) · Review
Structured evidence synthesis on the clinical impact of sinonasal biofilms in CRS.
PubMed · DOI · PMID 42233275 -
From Tregs to tissue remodelling: FOXP3 and IL-35 in the inflammatory landscape of nasal polyps
Gokulakannan G et al. — Inflamm Res (2026-06) · Review
Narrative review of regulatory T-cell FOXP3/IL-35 dysregulation in nasal polyp inflammation and its therapeutic potential.
PubMed · DOI · PMID 42228169 -
Predictive value of TXNIP/NLRP3 signaling pathway expression in nasal polyps for postoperative recurrence of chronic sinusitis with nasal polyps
Lin X et al. — Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi (2026-06) · Original
Prospective study showing nasal-polyp TXNIP/NLRP3 expression independently predicts CRSwNP postoperative recurrence and improves a prediction model.
PubMed · DOI · PMID 42208971 -
Disease-specific differences in particulate matter handling drive pathogenic responses in human derived nasal epithelial cells
Li Y et al. — bioRxiv (2026-05) · Preprint
Single-cell study (preprint) showing CRS nasal epithelium amplifies particulate-matter-induced inflammation and barrier dysfunction via endocytic uptake.
PubMed · DOI · PMID 42239414 -
Fractional exhaled nitric oxide and nasal nitric oxide as biomarkers in chronic rhinosinusitis
Solinas A et al. — Curr Opin Allergy Clin Immunol (2026-05) · Review
Review of FeNO and nasal nitric oxide as complementary noninvasive biomarkers for CRSwNP endotyping and monitoring.
PubMed · DOI · PMID 42235000 -
Ca2+ signaling in chronic rhinosinusitis with nasal polyps: Deciphering mechanistic insights and future therapeutic targets
Kalaji Z et al. — J Adv Res (2026-05) · Review
Review (with in silico analysis) of calcium-channel signaling, including KCa3.1, as a candidate therapeutic target in CRSwNP.
PubMed · DOI · PMID 42219029 -
Epithelial SERPINB2 Overexpression Contributes to Impaired Fibrinolysis in Chronic Rhinosinusitis With Nasal Polyps via tPA Downregulation
Zhu Y et al. — Front Biosci (Landmark Ed) (2026-05) · Original
Mechanistic study identifying a SERPINB2-tPA axis driving impaired fibrinolysis in nasal polyps as a potential therapeutic target.
PubMed · DOI · PMID 42216541 -
CBC-Derived Biomarkers Associated With Recurrence After Sinus Surgery in Chronic Rhinosinusitis
Kirtsreesakul V et al. — Laryngoscope (2026-05) · Original
Retrospective cohort showing higher absolute eosinophil count and systemic immune-inflammation index are associated with long-term CRS recurrence after ESS.
PubMed · DOI · PMID 42212465 -
Serum metabolic biomarkers associated with self-reported chronic rhinosinusitis: a population-based cross-sectional study from the KNHANES
Chen H et al. — Braz J Otorhinolaryngol (2026-05) · Original
Population-based study finding higher serum uric acid associated with CRS prevalence.
PubMed · DOI · PMID 42208086 -
Distinct Histopathological and Transcriptomic Signatures of Central Compartment Atopic Disease
Han L et al. — Int Arch Allergy Immunol (2026-05) · Original
Multicenter study characterizing central compartment atopic disease as a type 2 endotype with eosinophil-rich stromal remodeling and distinct mast-cell/macrophage transcriptomic features.
PubMed · DOI · PMID 42207779 -
Association Between Fungi and Postoperative Recurrence in Eosinophilic Chronic Rhinosinusitis
Adachi N et al. — Am J Respir Crit Care Med (2026-05) · Original
Mycobiome study linking sinonasal fungi (e.g., Alternaria) to postoperative recurrence in eosinophilic CRS.
PubMed · DOI · PMID 42203684 -
Pathway-Specific Effects of Oral Corticosteroids on Eosinophilic Inflammation and Tissue Remodeling in Chronic Rhinosinusitis with Nasal Polyps
Radajewski K et al. — Int J Mol Sci (2026-05) · Original
Prospective immunohistochemistry study showing short-course oral corticosteroids reduce periostin/eotaxin and raise TGF-beta in CRSwNP polyp tissue.
PubMed · DOI · PMID 42196542 -
Novel CRS Subtypes Based on Clinical Features and Response to Treatment
Hamilos DL et al. — J Allergy Clin Immunol Pract (2025-11) · Cohort
MGH cohort (N=942) — clinically derived CRS classifiers that predict treatment response.
PubMed · DOI · PMID 41240050 -
Epigenetics in chronic rhinosinusitis
Kumar N et al. — Curr Opin Otolaryngol Head Neck Surg (2025-11) · Review
Review of epigenetic mechanisms in CRS pathogenesis.
PubMed · DOI · PMID 41442742 -
Cadherin-26 Facilitates Transepithelial Migration of Eosinophils in Eosinophilic CRS
Jo YI et al. — Int Forum Allergy Rhinol (2025-10) · Mechanistic
Mechanistic biomarker — cadherin-26 drives eosinophil transepithelial migration in eCRS.
PubMed · DOI · PMID 41091526 -
Explainable AI predicts inflammatory and spatial heterogeneity from nasal polyp histology
Wang K et al. — J Allergy Clin Immunol (2025-09) · Original
Explainable computational pathology on nasal polyp histology to predict inflammatory and spatial heterogeneity.
PubMed · DOI · PMID 40902945 -
Proteomic profiling and machine learning for endotype prediction in chronic rhinosinusitis
Morgenstern C et al. — J Allergy Clin Immunol (2025-09) · Original
Machine learning on nasal proteomics to predict CRS endotype.
PubMed · DOI · PMID 40939758 -
An anti-TSLP monoclonal antibody (CM326) for uncontrolled CRSwNP
Xian M et al. — Nat Commun (2025-09) · RCT (Phase 1b/2a)
Phase 1b/2a RCT of anti-TSLP mAb CM326 in uncontrolled CRSwNP, stratified by baseline tissue eosinophils.
PubMed · DOI · PMID 41022848 -
Epithelial-Derived Alarmins in CRSwNP
Cheng F et al. — Clin Rev Allergy Immunol (2025-06) · Review
Review of epithelial alarmins (TSLP, IL-33, IL-25) as CRSwNP therapeutic targets.
PubMed · DOI · PMID 40533675 -
The Evolution, Immunopathogenesis and Biomarkers of Type 2 Inflammation
Gao YD et al. — Allergy (2025-06) · Review
Review of type 2 inflammation immunopathogenesis and biomarkers across allergic disease.
PubMed · DOI · PMID 40586319 -
Tailoring Evaluations of CRS: Sleep and Memory Through Actigraphy
Moore D et al. — J Pers Med (2025-06) · Original
Actigraphy used to characterize sleep and its memory effects in CRS evaluation.
PubMed · DOI · PMID 40559111 -
Effects of inflammatory endotypes on disease trajectory in CRSwNP
Dorismond C et al. — J Allergy Clin Immunol (2025-04) · Cohort
Compares time-to-polyp-recurrence between CRSwNP inflammatory endotypes.
PubMed · DOI · PMID 40220908 -
Allergic Fungal Rhinosinusitis and Eosinophilic CRS: comparison
Nakayama T et al. — Int Forum Allergy Rhinol (2025-04) · Multicenter
Multicenter comparative study distinguishing AFRS from eosinophilic CRS.
PubMed · DOI · PMID 40299896 -
Proteomic profiling of nasal fluids and serum for type 2 nasal polyp diagnosis
Hou Y et al. — Ann Allergy Asthma Immunol (2025-04) · Original
Proteomic signatures in nasal fluid/serum for non-invasive type 2 polyp diagnosis.
PubMed · DOI · PMID 40280274 -
Long-Term Particulate Matter Exposure May Increase Risk of CRSwNP
Lubner RJ et al. — Int Forum Allergy Rhinol (2025-04) · Cohort
Epidemiologic link between long-term PM exposure and CRSwNP risk.
PubMed · DOI · PMID 40257454 -
Tezepelumab inhibits highly functional truncated TSLP in chronic rhinosinusitis
Oka A et al. — J Allergy Clin Immunol (2025-03) · Mechanistic
Mechanistic evidence that tezepelumab inhibits a truncated, highly functional TSLP isoform in CRS.
PubMed · DOI · PMID 40057283 -
Phenotyping and Endotyping Pediatric Chronic Rhinosinusitis
Morgan E et al. — Otolaryngol Head Neck Surg (2025-03) · Review/Original
Phenotype/endotype framework specific to pediatric CRS.
PubMed · DOI · PMID 40111215 -
New insights into the endotypes of chronic rhinosinusitis in the biologic era
Wang M et al. — J Allergy Clin Immunol (2025-02) · Review
Updated framework for CRS endotypes in the context of biologic therapy.
PubMed · DOI · PMID 39986619
Sources indexed via PubMed (NCBI). Each entry links to its PubMed record and DOI.